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An annoyance
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Any large scale calamity (especially when thought to be sent by God)
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A swarm of insects that attack plants
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A serious (sometimes fatal) infection of rodents caused by Yersinia pestis and accidentally transmitted to humans by the bite of a flea that has bitten an infected animal
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Any epidemic disease with a high death rate
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Annoy continually or chronically
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Cause to suffer a blight